If there is black stool with blood vomiting, it indicates the existence of upper gastrointestinal bleeding, and the treatment drugs include drugs to inhibit gastric acid secretion, growth inhibitors, hemostatic drugs, and drugs to prevent bleeding. 1. Drugs to inhibit gastric acid secretion: such as omeprazole, lansoprazole, etc., which are suitable for patients with bleeding due to gastric mucosal ulcers. 2. Growth inhibitors: such as growth inhibitor analog octreotide, which can relieve portal hypertension and reduce the bleeding of gastric submucosal varicose veins. 3. Hemostatic drugs: e.g., phenolsulfonamide, tranexamic acid, etc., can be used until the cause of bleeding is identified. 4. Prevention of bleeding: e.g. propranolol, after controlling variceal bleeding, propranolol is applied to prevent rebleeding. If there is black stool with vomiting blood, it is recommended to consult the doctor in time to identify the cause and treat it actively to avoid hemorrhagic shock.