Protein deficiency, also known as hypoproteinemia, is characterized by decreased plasma protein, decreased colloid osmotic pressure, and generalized edema. [Most protein deficiencies are secondary to other diseases. Insufficient protein intake or impaired absorption, such as esophageal stricture, chronic diarrhea, etc. Excessive protein consumption such as massive blood loss, severe burns, febrile diseases, malignant tumors, cachexia, pleurisy, peritonitis, glomerulonephritis, nephrotic syndrome, etc. Protein synthesis is hampered by liver diseases, such as cirrhosis, chronic hepatitis, etc. [Symptoms] Sick dogs show emaciation, coarse coat, weight loss and growth arrest. Loss of appetite, visible mucous membrane pallor, and decreased blood pressure. In severe cases, generalized edema appears. Resistance decreases and secondary infection easily occurs. [Diagnosis] Adult dogs have a total plasma protein content of 5.3-7.5 g% and albumin of 3-4.8 g%. If total plasma protein decreases to less than 5 g% and albumin to less than 3 g%, protein deficiency can be considered. Due to the frequent occurrence of anemia, hemoglobin and red blood cells are reduced. [Treatment] Etiological treatment is the fundamental method to treat the disease for different causes. Food bait therapy Give protein-rich and high-calorie foods, such as soy milk, milk, fish, meat, eggs, etc., and supply protein at 2-3g/kg/day. The amount of food should be increased slowly for those with diarrhea to avoid indigestion. In cases with more severe edema, the administration of salt can be temporarily restricted. Supplementation of amino acid preparations Depending on the condition, amino acid preparations, vitamins, grape enamel, hydrolyzed protein, etc. can be given appropriately. Blood transfusion Blood transfusion should be given to those with severe anemia.