The main treatment for acute necrotizing pancreatitis is surgical incision and drainage. Because necrotizing pancreatitis is complicated by a large amount of fluid in the abdominal cavity and infection, which leads to the development of abdominal septal compartment syndrome, the organs of the abdominal cavity are compressed and circulatory dynamics are affected, so surgical incision and decompression is performed along with active anti-shock and anti-infection treatment. Intraoperatively, necrotic pancreatic tissue is removed for drainage, and after surgery, lavage and irrigation of the abdominal cavity is also required, which can be performed with the application of antimicrobial agents, with the main purpose of controlling infection. Intravenous plasma and human albumin should be supplemented to increase the plasma colloid osmotic pressure and reduce tissue exudation, and the abdominal drainage and pancreatic enzymes should be monitored to prevent respiratory infections or complications related to organ insufficiency.