The presence of sinus arrhythmia ST segment changes may be related to heart diseases such as hypertension, coronary artery disease, heart valve disease, cardiomyopathy and other diseases. 1. Hypertensive disease: Patients with elevated blood pressure need to provide more power to the cardiomyocytes to expel blood from the heart, resulting in increased pressure on the blood supply to the cardiomyocytes, leading to sinus arrhythmia ST-segment changes. This condition needs to be treated with antihypertensive drugs such as amlodipine benzoate tablets and valsartan capsules under medical prescription. And regularly test the blood pressure to detect the abnormal increase of blood pressure; 2. Coronary heart disease: the coronary arteries of patients with coronary heart disease may be narrowed, resulting in insufficient blood supply to the coronary arteries, resulting in patients with sinus arrhythmia ST-segment changes. This condition requires antiplatelet coagulation therapy with aspirin enteric tablets, clopidogrel hydrogen sulfate tablets and other drugs as prescribed by the doctor. If necessary, interventional procedures can be received; 3. Cardiomyopathy: such as hypertrophic cardiomyopathy, dilated cardiomyopathy, etc. Cardiomyopathy may cause insufficient blood supply to the heart muscle due to hyperplasia of the heart muscle tissue, resulting in patients with sinus arrhythmia ST segment changes. Treatment requires the use of drugs such as Benadryl hydrochloride tablets and coxsartan potassium tablets under medical advice to delay heart failure. In life, attention should be paid to adjusting lifestyle habits, a light, easy-to-digest diet, and try not to eat greasy, too sweet, spicy and other foods. At the same time, attention should be paid to rest and avoid overexertion; 4, heart valve disease: heart valve disease can be caused by abnormal heart valve function causing regurgitation or obstruction of blood to the heart, resulting in a decline in heart function, so that the heart’s blood perfusion is reduced and sinus arrhythmia ST segment changes occur. Treatment requires timely surgical treatment, such as prosthetic valve replacement, heart valve repair, etc.; 5, other: some normal people who have overworked, long-term stay up late and other bad habits can make the heart work excessively, resulting in increased myocardial oxygen consumption, causing myocardial ischemia, hypoxia, sinus arrhythmia ST-segment changes. This condition usually does not require special treatment, and can be relieved by paying attention to rest and changing bad habits. In case of sinus arrhythmia ST segment change, you should pay attention to rest, develop good diet and living habits, eat lightly, sleep early and wake up early, avoid staying up late and strenuous exercise.