Smearing tacrolimus to get whiter and whiter, it usually takes 6-9 months to gradually recover. Tacrolimus belongs to a kind of immunosuppressant, after applying on the skin surface, some patients may cause local skin immune metabolism dysfunction, and very few patients will have skin hypopigmentation. This kind of hypopigmentation is a kind of temporary hypopigmentation, its subcutaneous melanocytes produce less pigment, so it will become whiter and whiter. After stopping the use of tacrolimus, through the metabolism of the immune system, the amount of pigment produced by melanocytes gradually returns to normal, and will gradually return to normal skin color. However, it will take 6-9 months to reach the original skin color. It should be noted that Tacrolimus has a certain degree of irritation, some patients may experience burning, erythema and other phenomena on the surface of the skin after use, which is normal and nothing to worry about.