Rotavirus enteritis is one of the common diseases among infants and children in China, with the highest incidence among infants and children aged 6 months to 2 years and half of them within 1 year. It is one of the main causes of malnutrition and growth disorders in children. It can mainly cause dehydration and electrolyte disorders, and there is no specific drug treatment. We have applied Mamma’s love combined with ribavirin and Similac to treat acute rotavirus enteritis in infants and children, and received good therapeutic effect. There were 58 children, 32 males and 26 females; ages ranged from 7 months to 28 months. There were more than 5 yellow egg-flower-like dilute watery stools without pus and blood within 24 hours before the visit, and a little mucus and occasionally a few white blood cells were seen on routine microscopic examination of stool. The colloidal gold method was used to detect positive fecal rotavirus (RV) in group A. There were 8 cases with routine blood WBC >10×109/L and 3 cases with CRP >8 mg/L. No antiviral, antibiotic and microecological agent treatment was given before the visit, and there was no moderate or severe dehydration, and some were accompanied by mild vomiting. There was no significant difference in age, gender and condition among all the enrolled cases by statistical treatment, and they were comparable. All the enrolled cases were randomly divided into two groups according to the order of consultation: control group: 29 cases treated with ribavirin combined with Simethicone; treatment group: 29 cases treated with mometho on top of the treatment in the control group. Dosage and usage: Ribavirin usage: 10mg/kg?d, divided into 3 oral doses; Similda (montelukast) usage: 1g/dose under 1 year old, 1.5g/dose over 1 year old, 3 times/day; Mamia (Bacillus subtilis dibacterium granules) usage: 0.5g/dose under 1 year old, 1g/dose over 1 year old, 2 times/day; Similda was instructed to be taken alone, with other drugs The interval between administration and other drugs was 1.5 to 2 hours. In all cases, ORS oral rehydration solution was given and diet was instructed. Antibiotics and other antidiarrheal drugs were not used in all cases. The condition was evaluated every other day for the number of stools, their properties, and vomiting, and the follow-up was ended for those who were cured. Those whose condition did not improve or worsened after 3 days of continuous treatment were evaluated as ineffective and withdrawn from the study, and the treatment regimen was changed. The following indicators were used to assess the condition. Cured: complete disappearance of clinical symptoms, return to normal stool frequency, completely normal stool properties, and no vomiting. Improvement: clinical symptoms basically disappeared, stool frequency decreased to 2 times/day, stool properties improved significantly compared to before, occasional vomiting. Ineffective: no improvement in clinical symptoms, no reduction in the number of stools and no improvement in stool properties, still vomiting and even aggravation. The efficacy of the treatment group was significantly better than that of the control group. Rotavirus (RV) is the main virus causing diarrhea in infants and young children, and it often occurs in autumn and winter every year, so it is called autumn diarrhea. It is characterized by rapid onset and excretion of characteristic egg-flower-like dilute watery stools, which are watery and contain a large amount of electrolytes, easily causing dehydration, acidosis and electrolyte disorders. This leads to changes in the intestinal environment, which destroys the environment in which normal microorganisms live, and a vicious circle can be formed between diarrhea and a serious imbalance in the intestinal microecosystem. Among viral diarrhea, rotavirus enteritis has the highest incidence, accounting for about 40%. Currently, there is no specific drug treatment for rotavirus enteritis. The main treatment principles are antiviral, symptomatic rehydration, correction of electrolyte disorders, restoration of the normal ecological environment of the intestinal tract, and inhibition of the reproduction of intestinal pathogenic bacteria. Ribavirin is a broad-spectrum antiviral drug, which is quickly absorbed orally and has fewer side effects than intravenous drugs and intramuscular injections. Simethicone has a strong adsorption and fixation effect on viruses and bacteria in the digestive tract, and a strong covering ability on the mucous membrane of the digestive tract. Mammazine contains Bacillus subtilis, Enterococcus and many kinds of vitamins, calcium and zinc. The first two are intestinal probiotics, which can directly supplement the normal physiological flora of human body and block the combination of germs and intestinal cells. Its decomposition of sugars in the intestine to produce lactose can increase the acidity in the intestine, rebuild the body’s natural barrier, inhibit the growth of viruses and harmful bacteria, resist the invasion and colonization of rotavirus, and inhibit the production and absorption of toxins of intestinal origin. The B-vitamins, calcium and zinc in Mamma Aide also promote the regeneration and repair of damaged intestinal mucosa. The results of our study showed that the combination of Mamia, Ribavirin and Simethicone in the treatment of rotavirus enteritis in infants and young children could shorten the duration of diarrhea, reduce the number of stools, change the stool properties and reduce the water content of stools. The treatment group was significantly better than the control group both in terms of cure rate and total effective rate. And no toxic side effects were found during the treatment. The combined application of the three drugs in the treatment of rotavirus enteritis without the use of antibiotics avoided the disorder of intestinal flora to the greatest extent and avoided the secondary infection caused by diarrhea, and this method is suitable for application and promotion in children who are not accompanied by moderate or severe dehydration.