Phytoneurological disorders may cause chest pain, while care should be taken to differentiate them from chest pain caused by chest wall diseases, cardiovascular diseases, and respiratory diseases. Most of the vegetative nerve dysfunction is caused by a cluster of symptoms after prolonged psychological stress, mental tension, and mental stimulation. Autonomic nerves mainly innervate internal organs, blood vessels, glands and smooth muscles, and the dysfunction also tends to appear in the central nervous system, as well as circulatory, digestive and endocrine systems, resulting in a series of dysfunctional symptoms, chest pain being one of the symptoms. Chest pain can also be caused by intercostal neuritis of the chest wall, coronary heart disease, pulmonary infarction, pleurisy, pneumothorax and other chest diseases, and should be distinguished from chest pain caused by autonomic disorders. Patients are advised to seek prompt medical attention, consult a specialist, and follow medical advice for further examination and treatment.