Progressive ossifying myositis is a rare congenital hereditary connective tissue disorder that presents with progressive ossification of connective tissue throughout the body in stages and bilateral symmetrical abnormal finger (toe) development. Due to ossification of the pectoral muscles, it leads to breathing difficulties or death due to inability to eat due to ossification of the masticatory muscles, or death due to multisystem infection caused by prolonged bed rest due to stiffness of the trunk, for which there is no exact and effective treatment. There are three types of ossifying myositis: 1) traumatic limited ossifying myositis: limited ossification of muscles in certain areas due to external injury; 2) non-traumatic limited ossifying myositis: limited ossification of muscles without significant external force; 3) congenital progressive ossifying myositis: acquired from congenital genetic factors, and generalized, multiple, progressive ossification. Congenital progressive ossifying myositis, an extremely rare hereditary connective tissue disorder, is difficult to trace back to family history because of its low incidence, high disability and low rate of marriage. It is characterized by a young age of onset and occurs mainly in the transverse muscles, ligaments, tendons, fascia and skin. Each site has infection-like symptoms such as redness, swelling, heat, and pain before ossification, and the symptoms may disappear on their own without treatment. Congenital progressive ossifying myositis is a rare dominantly inherited connective tissue lesion with generalized, progressive, multiple ossification. The disease was first described by Patin in 1692 in a patient with “dead twig-like people”, later also called “coral people”, and is probably due to a congenital genetic deficiency of some components of the connective tissue, with early marked interstitial edema The disease is probably caused by a congenital genetic deficiency of certain components of the connective tissue, with marked interstitial edema and intra-connective tissue proliferation in the early stages, secondary atrophy and degeneration of the muscle fibers, and calcification and ossification of the mesodermal tissue in the later stages, not due to trauma. The disease begins in infancy and is characterized by congenital skeletal abnormalities and progressive soft tissue ossification. The developmental abnormalities are mainly manifested by symmetrical abnormalities of the little fingers of both hands and bunions of both feet, short deformities, and bunions. This feature is present in every case and is an important diagnostic basis. Soft tissue ossification is mostly seen in the transverse muscles, ligaments, tendons, fascia and skin, but the tongue, larynx, diaphragm and sphincter are not invaded. The lesion progresses in stages until most of the connective tissues, muscles and joints ossify and stiffen, and the ossified muscles may be flattened, striated or reticulated. The ossification occurs along the course of muscle fibers and can be connected to bones, and bony bridges can be formed between adjacent bones, resulting in joint stiffness. The ossification of the ligaments around the spine can narrow the vertebral space and cause a “bamboo joint”-like change. The muscles, fascia, ligaments and tendons of the whole body gradually ossify and stiffen, and eventually the torso becomes deformed and the joints become immobile due to stiffness. Due to the extensive ossification of the pectoral muscles, it causes respiratory failure due to difficulty in breathing, or death due to inability to eat due to ossification of the masticatory muscles, or death due to multi-system infection caused by prolonged bed rest due to rigidity of the torso. There is no effective treatment to slow down the progression of the disease. Hormone, steroid and radiation therapy have not been effective in this disease. Surgical procedures to remove ossified tissues may cause more severe ossification than the original ossification to reappear in the same area within a short period of time due to traumatic factors, so it is important to stop bleeding thoroughly intraoperatively for patients who have to undergo surgery as a last resort.