Intracranial infection is a serious complication encountered from time to time in neurosurgery, and is also a very complex and difficult to treat condition. If the treatment is not timely and improperly handled, it may lead to serious consequences, and the disability and mortality rates are very high. So many patients or family members are worried about whether intracranial infection can be cured. There are many types of intracranial infections, such as intracranial infection after craniotomy, intracranial infection with extraventricular drainage, intracranial infection with septic and tuberculous meningitis, intracranial infection with extraventricular or lumbar pool drainage, and so on. There are also different pathogens for the treatment of intracranial infection, including bacteria, virus, parasites, mycoplasma, chlamydia, mycobacteria, rickettsia and other pathogens, all of which can cause intracranial infection after invading the cranium. Then the difficulty of treatment of intracranial infection is also related to these pathogens. For example, the general ones are mostly gram-positive coccus infections, which may be relatively easy to treat; but if they are drug-resistant superbug infections, such as Acinetobacter baumannii and Klebsiella pneumoniae, then conventional anti-infection treatment is generally ineffective and the treatment difficulty is quite high. But generally speaking overall, there are also good ways to treat them. So intracranial infection is not terrible, timely and correct treatment is the key. Therefore, abnormal symptoms should be detected early and treated promptly. Once a patient has symptoms such as unexplained high fever, cervical tonicity, patient’s impaired consciousness, abdominal distension, etc., high attention should be paid and cerebrospinal fluid should be promptly retained for culture, routine, biochemical and other tests according to the situation. And carry out the special technology treatment of cerebrospinal fluid specialist, there is still great hope for recovery.