What does it mean when cirrhosis causes the spleen to become congested and enlarged? We all know that once cirrhosis is formed, it will cause the liver to become hard in texture and a large amount of fibrous tissue proliferation in hepatocytes, accompanied by the formation of pseudobullets, which will compress the capillary bile ducts and intrahepatic vessels. As the splenic vein and superior mesenteric vein converge to form the portal vein, once the portal vein pressure increases, it will cause the splenic vein and superior mesenteric vein to block the blood return and the spleen will become congested and swollen. If the cirrhosis is severe and the portal vein pressure continues to rise progressively, it will cause the spleen to become congested and hypersplenic, and the spleen will increase significantly in size, and some patients can even feel the enlarged spleen at the level of their belly button. Hypersplenism leads to massive destruction of blood cells and a decrease in white blood cells, platelets, red blood cells, and neutrophils, reducing the immune system of the patient. A significantly enlarged spleen increases the likelihood of spleen rupture, which can lead to abdominal hemorrhage and endanger the patient’s life. In addition, an oversized spleen can crush the gastrointestinal tract and cause stasis of blood in the gastrointestinal tract, resulting in indigestion, abdominal distension and other symptoms. Surgical removal of the spleen is the most common treatment for patients with a giant spleen.