Drugs that can treat premature ejaculation by affecting the central nervous system include dapoxetine hydrochloride, sertraline and paroxetine. Clinical drugs used to treat premature ejaculation are mainly 5 hydroxytryptamine reuptake inhibitors, which can inhibit neuronal uptake of 5 hydroxytryptamine, thereby affecting signaling between nerve cells, regulating ejaculatory reflexes, and prolonging the latency of ejaculation. Such drugs include dapoxetine hydrochloride, paroxetine, sertraline and so on. In addition to medication, ways to improve premature ejaculation include psychological/behavioral therapy and surgery. It is recommended to choose the appropriate treatment plan according to your specific situation under the guidance of your physician, and it is not advisable to use drugs indiscriminately to avoid affecting your condition or causing other adverse consequences.