Leprosy is an infectious disease caused by Mycobacterium leprae, which can generally be cured with active treatment in the early stages. The emergence of leprosy requires strict compliance with medical advice to avoid incomplete treatment and relapse of the disease. The main clinical treatment is a combination of drugs, commonly used in the treatment of leprosy drugs such as aminophenazone, chlorophenothiazine, rifampin. The preferred drug is generally aminophenazone, which is mainly used to inhibit bacterial action and has a weak bactericidal effect. While rifampin can kill Mycobacterium leprae quickly, chlorophenothiazine can effectively inhibit Mycobacterium leprae. However, it should be noted that aminophenazone, chlorophenothiazine, and rifampin can cause different degrees of side effects, and the specific treatment requires the selection of the appropriate combination of drugs according to individual conditions. According to the strict treatment process, leprosy can generally be cured, the standard of cure is the skin smear turned negative, and then three months to review, two consecutive negative called clinical cure, you can stop the drug. However, leprosy is somewhat contagious, mainly through droplet transmission, contact transmission, leprosy patients are diagnosed, and their close family members need to be screened and tested. There is no vaccine to prevent the occurrence of leprosy, so we should pay attention to strengthening the awareness of self-protection in daily life, early detection and early treatment to avoid further development of the disease in later stages, invasion of nerve fibers, nerve thinning, hardening and dysfunction, and if the leprosy bacillus invades deep tissue will lead to deformities of the limbs.