Human papillomavirus (HPV) is the causative agent of condyloma acuminatum, and HPV infects only humans and not other animals. The human population is generally susceptible to HPV, especially adolescents between the ages of 16 and 30. The source of infection is the patient and a healthy person with the virus. Transmission is mainly through direct contact, and to a lesser extent through indirect contact. People with trauma are susceptible, and those who are immunocompromised (e.g., diabetes, systemic lupus erythematosus, AIDS, organ transplants, hormone administration, pregnant women, etc.) are more likely to be infected. A large number of foreign studies on HPV infection in different populations have found that in normal women, HPV detection rates range from 1.5% to 44.3%; in men, HPV positivity rates in the urethra and perianal area range from 12% to 28%; more than 50% of sexually active adults have been infected with more than one HPV virus, mostly subclinical or latent infection; and in asymptomatic adult The detection rate of cervical HPV is as high as 80% among asymptomatic adult women. A study in the United States investigated thousands of cases in the normal population, and the results showed that only 1% of HPV-infected patients showed acromegaly, indicating that HPV infection in the population, especially in sexually active people, is widespread, but the vast majority have no clinical symptoms and are merely carriers of the virus, and only a very small number of virus-infected patients develop symptoms and show acromegaly; in other words, the clinical appearance of In other words, the clinical appearance of warts is only the tip of the iceberg of HPV infection.