Persistent mycosis fungoides can be cured by general treatment, medication and other treatments. But the specific efficacy varies from person to person. 1. General treatment: pay attention to the hygiene and cleanliness of the vulva and change underwear frequently. At the same time, we should actively eliminate possible triggers, such as stop using broad-spectrum antibiotics. 2. Drug treatment: commonly used drugs are clotrimazole preparation, miconazole preparation and mycotoxin preparation and other topical drugs and fluconazole and other oral preparations. Persistent patients can carry out fungal culture of vaginal secretion and drug sensitivity test before drug treatment, and choose suitable sensitive drugs according to the results. 3. Other treatments: Generally there is no need to carry out routine treatment for sexual partners, but if sexual partners have glans inflammation, they should carry out Pseudomonal yeast examination and treatment in order to avoid repeated infections in female patients. The use of specific drugs should be under the guidance of the doctor, it is recommended to consult a doctor in a timely manner for diagnosis and treatment.