Sclerositis is an infectious disease of the sclera that begins with redness and loss of vision and is characterized by severe eye pain. It is also known as deep scleral infection. It manifests as a restrictive inflammatory infiltrate with acute scleral congestion, vascular tortuosity and obstruction, typically manifested as a restricted patchy avascular zone. Etiology: 1. Wegener’s granulomatosis (30%): Its pathology is characterized by inflammation of the vascular wall, mainly invading the upper and lower respiratory tract and kidneys, usually starting with focal granulomatous inflammation of the nasal mucosa and lung tissue and progressing to diffuse necrotizing granulomatous inflammation of the blood vessels. Clinical manifestations often include nasal and paranasal sinusitis, pulmonary lesions, and progressive renal failure. 2. Recurrent polychondritis (35%): progressive inflammatory destructive lesions with recurrent episodes and remissions involving cartilage and other systemic connective tissues, including the ear, nose, eye, joints, respiratory tract, and cardiovascular system. Clinical manifestations include chondritis of the ear, nose, and respiratory tract with symptoms of involvement of the eye, ear vestibule, and other organs. 3. Herpes zoster (25%): Children who are not immune to the virus are infected and develop chickenpox. Some patients are infected and become viral carriers without developing symptoms. Because the virus is neurophilic, it can be latent in the neurons of the posterior root ganglion of the spinal nerve for a long time after infection. When the resistance is low or when you are tired, infected or have a cold, the virus can grow and multiply again and move along the nerve fibers to the skin, causing intense inflammation of the invaded nerves and skin.