Dry socket is one of the common complications after dental extraction in oral surgery clinics, which is essentially an osteotomy infection. The author used dexamethasone combined with spiramycin to treat dry socket and achieved more satisfactory results. 1, Data and methods 1.1 General data A total of 23 cases were diagnosed as dry socket, 17 males and 6 females, aged 20-50 years. 1.2 Methods Under local anesthesia, the necrotic tissue was first scraped off with a scraper, and then the alveolar sockets were repeatedly rinsed with 3% hydrogen peroxide and saline alternately until they were clean. Patients were asked to bite sterile cotton balls for 30 min, and were asked to follow up within 3 days. 1.3 Judgment of efficacy Effective: pain disappeared; ineffective: no improvement of pain. 2. Results There were 23 cases in this group, 21 cases were treated effectively and 2 cases were not effective. The effective rate was 91.3%. 3.Discussion Dry socket is a kind of osteotomy infection caused by comprehensive factors, which mainly occurs after the extraction of mandibular obstructive wisdom teeth, and the incidence is between 10% and 30%, and 14.1% is reported in China [1]. Currently, trauma and infection and large extraction sockets are mostly considered as its main etiology. The diagnostic criteria are: (1) severe pain 2-3 days after tooth extraction, which may radiate to the auriculotemporal region, submandibular region and the top of the head, and the pain cannot be stopped by general analgesic drugs; (2) the extraction fossa may be empty, or there is a residual blood clot of decay and degeneration; (3) probing pain is obvious. The main manifestation of dry socket is severe local pain, so the main purpose of treatment is to rapidly relieve pain, eliminate bone wound infection and promote granulation tissue growth. Dexamethasone has a strong anti-inflammatory effect, which can counteract inflammation caused by various reasons such as physical, chemical, biological, immune, etc. Dexamethasone can also stimulate the hematopoietic function of bone marrow, increase the content of red blood cells and hemoglobin, increase platelets and raise the concentration of fibrinogen, shorten clotting time, help blood clot formation, and play a role in protecting the alveolar sockets. Dexamethasone also prevents postoperative tissue reactions and reduces swelling and pain. Acetospiramycin has the effect of inhibiting or killing G+ and G- bacteria and Streptococcus pyogenes and mucoid and actinomycetes. Gelatin sponge acts as a drug carrier to bring the drug into the extraction wound and it has the effect of promoting coagulation, which ensures the formation of blood clot and blocking the alveolar fossa thus promoting the growth of granulation tissue and isolating the adverse external stimuli. The efficacy in this data is obvious, and it is convenient, safe, effective and economical, which is worth using in primary hospitals.