Body temperature over 40 ℃ need to be promptly antipyretic drugs, because persistent high fever is the most damaging to various organs and tissues of the body, especially the brain, and improper handling can lead to serious sequelae. Therefore, when the body temperature appears 40 ℃, must cause enough positive attention, especially in the case of the application of antipyretic drugs is not effective must be promptly admitted to hospital treatment. Body temperature over 40 ℃, at this time the body metabolism accelerates, oxygen consumption increases, a lot of hydration at the same time to apply oral antipyretic drugs, such as acetaminophen tablets or ibuprofen extended-release capsules. If the effect of 4 hours of medication is not good, you need to go to the hospital in time to apply aminopyrine, lysine intramuscularly or intravenously to reduce fever, and if necessary, apply hormone symptomatic treatment. When children have febrile convulsions, they should be sedated with drugs such as diazepam, and at the same time, intravenous antipyretic drugs should be administered to lower the temperature. Persistent high fever is probably due to the presence of certain inflammatory diseases, viral infections, malignant tumors, immune diseases or infectious diseases in the organism, and the cause should be promptly identified in the hospital, and reasonable treatment should be given to the cause, while symptomatic treatment such as fever reduction should be actively carried out to reduce the damage to the organism. In conclusion, the appearance of persistent high fever is an alarm signal of disease in a certain part of the body and must be taken seriously. First of all, we should avoid blindly using antipyretic drugs, and we need to go to the hospital in time to clarify the cause of the disease and treat it for the cause.