Cholestasis in pregnant women, professionally known as intrahepatic cholestasis of pregnancy (ICP), occurs mainly in the middle and late stages of pregnancy and is characterized by itchy skin and elevated bile acids, which can cause fetal hypoxia, premature delivery, or even fetal death in utero in severe cases. Cholestasis in pregnant women can be judged by symptoms and clinical examination. Typical symptoms of cholestasis are itching of the skin, extending from the palms of the hands, feet, and around the umbilicus to the extremities, trunk, and face. A few patients may present with non-specific symptoms such as jaundice and gastrointestinal manifestations such as nausea, vomiting and loss of appetite. Pregnant women with these symptoms can be initially considered to have cholestasis, and the diagnosis can be confirmed based on laboratory tests. The examination items include: 1. serum bile acid measurement: it is the main basis for diagnosis, total bile acid ≥10umol/L can confirm the diagnosis; 2. liver function measurement: most of the patients have mild to moderate elevation of portal aminotransferase and alanine aminotransferase, which is 2-10 times of the normal level, and some patients have mild to moderate elevation of serum bilirubin; 3. pathological examination: postpartum placental pathological examination shows that the placenta and amnion are different degrees of yellow and gray plaques, chorionic plate and amniotic membrane have bile salt deposition and other characteristics. What are the hazards of cholestasis in pregnant women? Cholestasis in pregnant women is harmful to both the fetus and the pregnant women themselves, and the hazards are as follows: 1, fetus: it is easy to cause premature birth, intrauterine distress, abnormal development, hypoxic ischemic encephalopathy, and even sudden death; 2, pregnant women: it affects the body’s absorption of vitamin K, causes abnormal coagulation function, leads to postpartum hemorrhage, or causes abnormal liver function of the mother-to-be, and causes abnormalities in glucose metabolism and lipid metabolism. metabolism, lipid metabolism abnormalities, etc. Once a pregnant woman is diagnosed with cholestasis, the following treatments can be given: 1. pay attention to more rest and manage according to high-risk pregnancy; 2. carry out systematic monitoring and symptomatic hepatoprotective treatment; 3. avoid eating high cholesterol food; 4. take vitamin K1 supplement in time; 5. consider taking oral bile acid-lowering drugs in early and middle pregnancy; 6. timely termination of pregnancy.