Bilirubin is an important clinical basis for determining jaundice and is an important indicator of liver function. Light yellow to dark golden yellow color of the skin and sclera is one of the main features of the etiology. Hemolytic jaundice is caused by the destruction of a large number of red blood cells, resulting in the formation of a large amount of unconjugated bilirubin, which exceeds the capacity of the hepatocytes to take up, bind and excrete it. On the other hand, the toxic effects of anemia, hypoxia and products of red blood cell destruction caused by hemolysis weaken the metabolic function of the hepatocytes for bilirubin, resulting in the retention of unconjugated bilirubin in the blood, which exceeds the normal level and jaundice. The clinical etiological mechanisms of the condition are classified according to the nature of the bilirubin as follows. Jaundice with predominantly increased unconjugated bilirubin 1. excessive bilirubin production; 2. impaired bilirubin uptake; 3. impaired bilirubin binding Jaundice with predominantly increased conjugated bilirubin can be caused by impaired transport and excretion of bilirubin in the hepatocytes or by simultaneous impaired bilirubin uptake, conjugation and excretion.