Deep wrinkles can be treated with injectable fillers, botulinum toxin injections, and surgery, and the specific method that works best will depend on the patient’s condition. 1. The collagen used in the collagen injection filling method is derived from the skin of calves and is used in the human body after special treatment. The specific operation is to inject collagen directly into the dermis, so as to achieve the effect of filling, the effect is better and long-lasting, but is not suitable for some too loose aging skin. 2. Botulinum toxin injection method is through local injection of botulinum toxin can make the local muscle fibers in a tense state, so as to achieve the effect of eliminating dynamic wrinkles in a short period of time, but the maintenance time is short, and the interval of about half a year need to repeat the treatment. 3. Facelift surgery treatment through the removal of excess skin tissue, and the skin pulling to make the local skin become flat and tight, the surgery has a quick effect. When choosing different methods to get rid of wrinkles, be sure to operate in regular beauty institutions or hospitals.