What kind of medication to take for a toothache at night needs to be judged according to the cause of the toothache, and can be treated with metronidazole, ornidazole and other medications as prescribed by the doctor. Night toothache may be gingivitis, periodontitis and other diseases, if the symptoms of toothache is more serious, generally can follow the doctor’s instructions to use metronidazole, ornidazole and other medication, but also with the use of celecoxib, to avoid aggravation of pain symptoms. Patients with toothache at night may also be acute pulpitis, this time simply rely on medication may not be able to alleviate the need for timely medical treatment for root canal treatment, so as to reduce the pressure on the pulp chamber, to avoid aggravation of pain symptoms. Usually pay attention to personal dietary hygiene, diligent brushing and rinsing, it is best not to often eat after brushing. Medications should be used under the guidance of a physician.