Chinese medicine is a “pure natural product”, and since China has been “medicine and food of the same origin” since ancient times, it is believed that Chinese medicine is not allergic. In fact, not only Chinese medicines such as injections and pills can cause allergic reactions, but even single herbal medicines can cause allergic reactions. Allergic reaction is a kind of abnormal immune reaction between foreign antigenic substances and antibodies in the body, regardless of whether it is a traditional Chinese medicine or a western medicine. There are many substances in herbal medicines that can induce allergic reactions, such as proteins, peptides, polysaccharides and other large molecules with complete antigenicity; some other compounds with smaller molecules can be combined with proteins in the body as semi-antigens to become full antigens, thus causing allergic reactions. Chemical components with biochemically active genes have the potential to become semi-antigens. Chinese herbal medicines can generally be divided into botanicals, animal medicines and mineral medicines, among which insects are the most common to cause allergies and are more recognized by many doctors in clinical practice. However, allergies caused by plant-based herbal medicines are not uncommon. It is now known that many pollens (such as acacia flowers, willow flowers, tsubaki flowers, spinach flowers, etc.) are important allergens, and pollens have common antigens among them, especially pollens of the same family, and cross-reactions can occur between them. It is known that pollen of the genus Asteraceae, Artemisiaceae, and Ragwort have strong common antigens, mostly acidic proteins with molecular weights greater than 10,000, and their antigenic activity depends on the intact protein structure. All these flowers are herbs of the plant family. There are more than 100 kinds of herbal medicines that can cause allergic reactions, and the common animal herbal medicines that can cause allergic reactions are white silkworm, leech, dried dragon, bee’s milk, squid bone, toad, etc.; the plant herbal medicines are fishy grass, heartwort, panacea, senna, salvia, safflower, rhubarb, sander root, panax ginseng, frankincense, ginseng, comfrey, kudzu, catkins, cogongrass, rhizome, rhizome, siberian, cucumber, cucumber, cucumber. The mineral class of Chinese medicine includes ice chips, starch, gypsum, etc. There is also a category of allergy related to Chinese medicine, such as bone marrow, dahurica, zhu huang, thornbush, wind, sage, etc. This category of Chinese medicine is photosensitive, and patients may develop solar dermatitis after taking it, which should also be noted in clinical application. According to other statistics, single Chinese medicines and their preparations with high frequency of allergic reactions are: Panax ginseng, smallpox powder, water frog, frankincense, myrrh, crow’s nest, Leigong vine, senna, centipede, Danshen injection, Banlangen injection, fishy grass injection, Chaihu injection, and Andrographis injection. Chinese patent medicines and compound preparations with high frequency of allergic reactions are: Qing Kai Ling Injection, Compound Dan Shen Injection, Shuang Huang Lian Injection, Qing Fever Relief Injection, Yin Gardenia Huang Injection, Yin Huang Injection, Hepatitis Spirit Injection, Ginseng and Mai Injection, Zheng Tian Wan, Liushen Wan, Niu Huang Shang Qing Wan, Dang Da Wan, Sanjiu Gastrodia, Niu Huang Detoxification Tablets, New Compound Da Qing Ye Tablets, Quick-acting Wind Capsules, Huo Xiang Zheng Qi Shui, Zheng Safflower oil, etc. Chinese medicine allergy often has little to do with usage and dosage, but rather with individual physical differences, such as genetic transmission, metabolic enzymes in the body and immune system. The symptoms of allergic reactions to Chinese medicine are the same as those of chemical drugs, and their severity cannot be ignored. There were 346 cases of allergic reactions to Chinese medicine, including 53 cases of anaphylaxis, accounting for 15.32%; 12 cases of exfoliative dermatitis and large sore epidermal necrolysis loosening type drug rash, accounting for 3.47%; 12 cases of allergic purple dropout, accounting for 3.47%; and 4 cases of allergic nephritis, accounting for 1.16%. It can be seen that allergic reaction to Chinese medicine is a more serious adverse reaction. The prevention and treatment of Chinese medicine allergy should not be ignored. According to the survey, most of those who have serious adverse reactions are allergic people. The history of drug allergy should be considered before using the medicine. For those who have a history of pollen allergy should be cautious with aster, atractylodes, dong, grass safflower, small thistle, artichoke, dandelion, celandine, artemisia, artemisia, mugwort, niu laozi, pelargonium, chrysanthemum and other drugs; allergic to heterogeneous proteins, cautious with worm-like drugs; topical drugs once contact dermatitis occurs, then immediately stop using, give anti-allergic treatment. During the use of drugs, closely observe the reaction of drugs, especially allergic or weak people must be more cautious with drugs, once there are allergic symptoms immediately stop drugs, symptoms of mild can use anti-allergic drugs such as paracetamol, diphenhydramine, promethazine (fenagine), or vitamin C, calcium preparations, etc., treatment, symptoms of heavy patients such as anaphylaxis should be immediately sent to the hospital to give epinephrine, dexamethasone, respiratory stimulants, elevated pressure, oxygen The patients with severe symptoms such as anaphylaxis should be sent to hospital immediately for treatment with epinephrine, dexamethasone, respiratory stimulants, pressure, oxygen, etc.