Currently there is no one-shot drug for premature ejaculation, patients with premature ejaculation can choose local anesthesia, 5-hydroxytryptamine reuptake inhibitors and other drugs to improve symptoms. 1. Local anesthesia: the use of local anesthetics on the surface of the penis, such as lidocaine, proparacaine, benzocaine and other drugs alone or in combination can reduce the sensitivity of the penis, which can prolong the time of ejaculation, thus improving the symptoms of premature ejaculation. 2. 5-hydroxytryptamine reuptake inhibitors: for patients with premature ejaculation disease complicated by depression, such drugs can be chosen, such as dapoxetine, paroxetine, sertraline and so on. To a certain extent, the symptoms of premature ejaculation can be improved. In addition, it is recommended that patients with premature ejaculation use drugs under the guidance of a doctor and not privately.