Abdominal discomfort and weakness may be caused by acute gastroenteritis, gastrointestinal cold, chronic gastritis and other disease factors. 1. Acute gastroenteritis: it can be caused by infectious or non-infectious factors, leading to abdominal pain, diarrhea, nausea, vomiting and other symptoms, and a large number of body fluids are lost, which will cause the symptoms of fatigue. 2. Gastrointestinal cold: when viruses or bacteria invade the body, it will lead to respiratory and gastrointestinal symptoms, and can be accompanied by systemic symptoms, diarrhea, abdominal pain, nasal congestion, runny nose, fatigue and other symptoms. 3. Chronic gastritis: abdominal discomfort, bloating, nausea, loss of appetite and other symptoms, atrophic gastritis may cause anemia and then weakness. It is recommended to go to the hospital when abdominal discomfort and weakness occurs, and ask the doctor to make a judgment to clarify the cause of the disease.