Trabecular meshwork pigmentation is a manifestation of the clinical diagnosis of pigmentary glaucoma. Pigmentary glaucoma (pigmentary glaucoma) is secondary open-angle glaucoma caused by pigment dissemination in the anterior segment of the eye. It is usually easily confused with iris pigment loss and uveitis symptoms, and is usually treated medically first, followed by laser therapy, and finally surgery is considered. Important risk factors affecting the onset and progression of PDS are: young people, males, myopia and Caucasians.PG is socially dangerous in that it develops at an age when people are beginning to reach the peak of their careers and thus has a significant impact on society and families. In Western societies, PG accounts for 1% to 1.5% of the total number of glaucomas.PDS generally occurs in young adults, with onset between 20 and 45 years of age, but it also occurs in older adults.The proportion of men and women with PDS is the same. However, men are more common in PG, and the ratio of men to women is about 3:1.The age of onset of PD is about 10 years later in women than in men, with an average age of 46-53 years, compared with an average of 34-46 years in men.PDS is more common than one might think. Myopia is a risk factor for PDS. It has been found that the higher the degree of myopia, the younger the age at which glaucomatous optic disc damage occurs. The depth of the anterior chamber has been found to be asymmetrical in patients with PDS who have significant asymmetry between the two eyes, as well as in the depth of the iridocorneal angle. Whites are more likely to develop the disease, and it is rare in people of color and rare in Orientals. Cases of PG have also been reported in mixed families and in blacks with albinism. Most cases of PDS/PG are disseminated and rarely have a family history. Shortly after the abnormal pigmentation in the anterior chamber was reported, families with Krukenberg’s shuttle were also reported. It was not until the 1980s that reports indicated that PDS could be a familial disease PDS is inherited in an autosomal dominant manner, and the gene associated with this syndrome is located at the end of the long arm of chromosome 7 (7q35-q36). Localization of the gene associated with this disease is the 1st step in isolating this gene and characterization of the gene will help to elucidate the pathobiochemical features of PDS. In addition other special conditions such as large eyes, large corneas can likewise be associated with PDS/PG occurrence. However, no risk of PDS has been found in congenital glaucomatous eyes with progressive enlargement of the eyeball.