There is no clinical statement that eye drops cannot be used before bedtime, and there are no clear regulations on the specific time of using eye drops. It is recommended that the majority of the population under the guidance of a professional doctor or pharmacist, according to their own situation to choose the appropriate use of time, in addition to the use of eye drops also need to pay attention to the following aspects: 1, avoid long-term frequent use: most eye drops contain certain preservative ingredients, long-term frequent use may stimulate the eye surface, causing discomfort symptoms. After using eye drops eye discomfort can be alleviated in a short period of time, but can not completely improve the symptoms of eye dryness. And long-term frequent use may also lead to aggravation of symptoms, and in serious cases even lead to dry eye disease and other eye diseases. If the eye drops are antibiotics, long-term use can also produce drug-resistant bacteria, increasing the difficulty of treatment; 2, avoid random storage: eye drops should not be used for more than 4 weeks after opening, and should not be placed in a strong light or refrigerator freezer storage. Should be placed in a cool place or refrigerator freezer as far as possible, should also pay attention to each use of eye drops should be tightened after the cap, so as not to enter the air, resulting in liquid leakage or contamination due to the entry of bacteria. It is recommended that the majority of people use eye drops scientifically and reasonably, avoid over-reliance on the use of eye drops to relieve eye fatigue, and pay attention to moderate eye use in daily life, maintain eye hygiene, and ensure adequate sleep to help reduce the symptoms of eye discomfort at the root.