Pancreatitis caused by ERCP surgery is more serious and dangerous. ERCP, i.e. transendoscopic retrograde cholangiopancreatography, is one of the most important diagnostic and treatment means for biliopancreatic diseases. Common complications after ERCP include acute pancreatitis, bleeding, perforation, infection, cardiopulmonary accidents and so on, among which pancreatitis is a common complication after ERCP, which can even lead to death in severe cases. The mechanism leading to post-ERCP pancreatitis is not particularly clear, and may be related to the operation of the pancreas, such as the stimulation of the duodenal papilla during intubation, sphincterotomy, in addition to intra-pancreatic ductal injection of contrast medium, repeated insertion of guidewire in the pancreatic duct can also trigger pancreatitis. Post-ERCP pancreatitis is more serious, if not actively treated, the same may occur multi-organ failure, shock, infection and other serious complications, therefore, should be actively comply with the doctor’s instructions for treatment. If you feel unwell, you should go to the hospital in time, and under the guidance of the physician, give targeted treatment after clarifying the cause.