The clinical manifestation of bilateral lower extremity venous thrombosis is mostly manifested as sudden edema with swelling and pain in both lower extremities, which cannot be relieved after resting, and the swelling and pain is obvious after standing. Lower extremity vein thrombosis is a dangerous disease, and if it is central deep vein thrombosis, that is, iliac-femoral vein thrombosis, it can easily dislodge and form lethal pulmonary artery embolism. The rate of dislodgement is higher after the occurrence of bilateral lower limb DVT, so it is important to visit the hospital promptly and perform ultrasound and D-dimer examination of both lower limb DVTs to make a clear diagnosis. Inferior vena cava filter implantation is recommended, and active and effective anticoagulation therapy should be performed to prevent the spread and dislodgement of thrombus. The specific condition should be judged according to the patient’s condition, and life-saving and anticoagulation treatment with a filter is the fundamental treatment.