Bone marrow cancer is a very common tumor disease nowadays, and many patients are extremely frightened after the emergence of bone marrow cancer, and many of them have already sentenced themselves to death, thinking that there is no cure for cancer as long as they are suffering from it. What are the symptoms of bone marrow cancer? 1.Bone damage: bone pain is the main symptom of the disease, which is the first symptom in 60% of cases and is the manifestation of tumor cell infiltration. It is the first symptom in 60% of cases and is a manifestation of tumor cell infiltration. It is most common in the spine of low back, but also in the sternum, ribs and limbs. The pain increases with activity and is prone to pathological fractures. If the tumor penetrates the bone and invades adjacent tissues, a mass may form, with localized bone elevation, which is elastic or audible when pressed. A sudden increase in pain often indicates a spontaneous fracture, commonly in the ribs. Fractures of the lower thoracic and lumbar spine may cause paraplegia. 2, anemia and bleeding tendency: almost all patients have varying degrees of anemia, which worsens with the development of the disease. It can be very serious in the late stage. Hemorrhage is due to thrombocytopenia, vascular damage and coagulation disorders, mainly due to skin purpura and mucosal bleeding. In the late stage, there may be internal bleeding and intracranial bleeding is one of the causes of death. 3, infection: due to the immune deficiency of the body, infection often occurs repeatedly during the course of the disease, which is often the reason for patients to seek medical attention. Common infections are common podococcal infections such as pneumonia and diplococcal pneumonia and other septic infections. Urinary tract infections and sepsis caused by Gram-negative bacilli are also common in advanced stages of leukopenia and leukocyte function defects. Infections are particularly common in advanced disease or during chemotherapy, manifesting as recalcitrant and not easily controlled by drugs. 4, renal damage: is also a significant feature of the disease, often occurring at the onset of the disease. As a result of different pathogenesis, it manifests as proteinuria concentration and acidification dysfunction, often without hypertension. Renal failure occurs in about 20% of cases. Uremia is also a common cause of death in this disease. What is the differential diagnosis of bone marrow cancer? 1. Reactive plasmacytosis: seen in tuberculosis, typhoid fever, autoimmune diseases, etc. Generally, bone marrow plasma cells do not exceed 10% and are all mature plasma cells. 2, other diseases that produce M protein: chronic liver disease, autoimmune disease, malignant tumors such as lymphoma, etc. can produce a small amount of M protein. 3, monoclonal immunoglobulinemia of undetermined significance (MGUS): M protein in serum is less than 30g/L, plasma cells in bone marrow is less than 10%, no osteolytic lesions, anemia, hypercalcemia and renal insufficiency. About 5% of patients eventually develop into multiple myeloma. 4.Bone metastatic carcinoma: mostly accompanied by osteogenesis, with increased bone density around the osteolytic defect and significantly elevated serum alkaline phosphatase. There is the presence of primary lesion.