Drinking alcohol with a cephalosporin can cause a disulfiram-like reaction, which can lead to discomfort and even be life-threatening for the patient. The combination of alcohol and most cephalosporin antibiotics produces a disulfiram-like reaction, and this type of reaction can cause great discomfort in patients. In mild cases, there may be rashes, erythema, papules and partial fusion, dizziness, vomiting, chest tightness, shortness of breath, palpitations, dyspnea and other symptoms, and even in severe cases, patients may suffer from loss of consciousness, shock coma and so on. The combination of cephalosporin antibiotics and alcohol will produce a chemical reaction. Therefore, it is recommended not to drink alcohol within one week after taking the medicine, and if it is unavoidable, you need to wait for 72 hours until the drug is metabolized before you can drink it. In addition, patients who experience any discomfort during the period should consult a doctor in a timely manner. In conclusion, patients should not drink any alcohol after taking antibiotics such as cephalosporin to avoid serious consequences.