Acute periapical pain is very heavy and very disruptive to daily life, even rest is not an option. However, the best approach for acute periapical infection is to seek medical help in the hospital, i.e., routine root canal evacuation to reduce apical pressure and jaw adjustment of the affected tooth, making the affected tooth less traumatic. If there is no immediate medical condition, you can first take some anti-inflammatory drugs, such as metronidazole and cephalosporins (no allergy), and painkillers, which may temporarily relieve the symptoms, not necessarily resolve them. You also need to seek the help of a doctor in time, after the treatment process of the doctor, plus the conventional antibiotics and painkillers, so that the best results. So once you find this condition, do not take the medication first on your own, it is best to seek professional medical help.