The world’s first IVF baby was produced by Steptoe and Edwards in the United Kingdom on July 25, 1978, and the first IVF baby was born in China in 1988, and more than 5 million IVF babies have been born worldwide as of 2015. However, there are still many families in China who are not successful in their first attempt at IVF. Knowing your enemy is the only way to win a hundred battles. Let’s find out what factors affect the success of IVF. IVF The success rate of IVF depends on many factors, including the endocrine and laboratory conditions, the skill level of the technicians, the age of the patient, the condition of the uterus and ovaries, and the presence of other diseases, among which the age of the woman has the most significant impact. The main factors can be divided into physiological and psychological factors. Physiological factors 1. Age is an important factor affecting the success rate of IVF and is a reflection of a normal and vigorous female reproductive system. As we age, the number of eggs decreases, the quality decreases, the fertilization rate decreases, the pregnancy rate decreases significantly, and the miscarriage rate increases. Studies say that the pregnancy rate for couples of childbearing age is only 20%. After women enter the age of 35, all body functions decline, with the reproductive system being particularly prominent. 2. Chromosomes In some couples with primary infertility or a history of bad pregnancies, conception can be accomplished through IVF technology PGS/PGD if the couple has normal chromosomal variants. 3. Intrauterine environment Such as endometrial polyps, endometritis, previous surgery or inflammation (tuberculosis is the most common) resulting in endometrial damage can affect embryo implantation, thus leading to failure of IVF procedure. 4. Infertility symptoms in pregnant people Older primary infertility, uterine malformation severe endometriosis, polycystic ovary syndrome patients, from severe oligozoospermia or the presence of a large number of malformed sperm in those, egg malformation or abnormal development, etc., in IVF treatment can achieve successful conception through Mia 3rd generation IVF. Psychological state factors Women with heavy psychological stress, their endocrine will be affected, the blood vessels are in a state of long-term contraction, affecting the local blood flow to the uterus and ovaries, and the tension of the nervous system will cause abnormalities in the release of some neuromediators, resulting in disorders in the contraction of the uterus and fallopian tube muscles, resulting in embryos not being able to bed and leading to treatment failure. Therefore, it is very important to release psychological stress, communication between the doctor and patient, and mutual understanding and encouragement between the couple. Thus, the psychological and mental state of the patient is an important factor that affects the success or failure of IVF treatment.