Intrahepatic lipid deposition is a pathologic description, and the difference between intrahepatic lipid deposition and fatty liver lies in the difference in severity of disease, symptoms, treatment and so on. 1. Different severity of disease: the content of lipid in normal liver is not more than 5%, intrahepatic lipid deposition refers to the lipid in the liver exceeds the normal value, but it does not have obvious effect on the function of liver and human body, it is usually the early stage of fatty liver, and with the development of the disease, fatty liver may be formed. Fatty liver is divided into mild, moderate and severe fatty liver, which can affect the function of the liver, and can also cause liver cell degeneration, edema, necrosis, which can further lead to liver fibrosis, cirrhosis, and even develop into liver failure. 2. Different symptoms: lipid deposition in the liver usually has no obvious symptoms. Patients with fatty liver may have right upper abdominal pain, fatigue, loss of appetite, etc. A few patients may have splenomegaly and signs of portal hypertension. 3. Different treatments: lipid deposition in the liver generally does not need special treatment, pay attention to lightness in daily life, avoid drinking alcohol and spicy and greasy food, strengthen exercise, control weight, and have regular medical checkups. Fatty liver needs to treat related pathogenic factors, such as obese patients can follow the doctor’s advice to use drugs such as orlistat, diabetics commonly used metformin, etc., if necessary, also need to consider bariatric surgery, liver transplantation. If the examination suggests intrahepatic lipid deposition, attention should be paid to dietary regulation and life adjustments to avoid aggravating the condition and progressing to fatty liver.