The preferred hypoglycemic agents for wasting diabetic patients are sulfonylureas and glinides. 1. Sulfonylurea: belongs to the insulin secretion agent, suitable for newly diagnosed non-obese type 2 diabetes mellitus, with diet and exercise treatment when blood sugar control is not satisfactory. Commonly used drugs mainly include glibenclamide, glipizide, gliclazide, gliquidone, glimepiride and so on. 2. Glargine: belongs to non-sulfonylurea insulin secretion promoter, suitable for non-obese type 2 diabetes mellitus postprandial hyperglycemia stage, or postprandial hyperglycemia mainly in elderly patients. Commonly used drugs include Repaglinide, Naglinide, Miglinide and so on. Diabetic patients sugar-lowering program to follow the individualization of the specific treatment drugs, please consult a physician, under the guidance of the physician standardized treatment.