The following reasons should be considered when there is pain in the heart during running: 1. whether the patient has coronary artery disease, after coronary artery disease myocardial ischemia, the reserve capacity of the heart decreases, the patient’s myocardial oxygen consumption increases when running, so that too many metabolites or peptides accumulate in the myocardium, stimulating the autonomic nerves in the heart, the patient will experience pain; 2. whether the patient has intercostal neuralgia. Intercostal neuralgia is not necessarily limited to the chest, most of them are stabbing or burning pain, and the pain will increase when the patient breathes hard while running, or when the body turns; 3, intercostal chondritis, intercostal chondritis is often pressure pain at the rib cartilage; 4, cardiac neuropathy, most of the cardiac neuropathy is a short-lived stabbing pain for a few seconds, and some patients will have a lasting hidden pain for several hours.