A lie down on the chest tightness and shortness of breath may be physiological factors, diseases, etc., according to the cause of the disease to follow the doctor’s prescription for symptomatic treatment. 1. Physiological factors: If you are in a space where the air does not circulate for a long time, or the spirit is too tense, can lead to chest tightness and shortness of breath when lying down, it is recommended to change the environment and regulate your mental state. 2. Disease factors (1) respiratory diseases: such as pneumonia, asthma, etc., can be prescribed by taking drugs, such as glucocorticoid prednisone to control asthma symptoms, pneumonia needs to be diagnosed after the use of amoxicillin, cephalexin and other drugs according to doctor’s orders for anti-infective treatment. (2) cardiovascular system diseases: such as heart failure, hypertension, etc., can take medication under the guidance of a doctor (such as hydrochlorothiazide, propranolol), cardiac resynchronization therapy, implantable cardioverter defibrillator, etc.. Relying only on a single symptom of chest tightness and shortness of breath as soon as you lie down, you can’t determine the cause of the disease and target it, you need to go to the hospital in a timely manner and carry out the relevant examinations, and then according to the doctor’s instructions for treatment.