The improvement of tacrolimus for halo nevus is manifested by the reduction of the size of the white spot or the color of the white spot becomes less obvious. Halo nevus is a special type of vitiligo, which mainly manifests as white spots around the original pigmented nevus and is caused by immune reaction. Tacrolimus is an immunosuppressant that can inhibit T-lymphocyte activation, and can be used to treat moderate to severe atopic dermatitis, as well as halo nevus. When used in the treatment of halo nevus out of the white spot area reduced or white spots become lighter in color, it suggests that the halo nevus is getting better. The use of tacrolimus should be under the guidance of medical professionals, common adverse reactions include burning sensation of the skin, hypertension, headache, etc. Tacrolimus is contraindicated in patients with a history of allergy to tacrolimus or any other ingredient in the preparation. The treatment of halo nevus is usually best to excise it and do pathological examination after excision. It is recommended that patients with halo nevus should seek timely medical attention and follow the doctor’s instructions for treatment.