The clinical manifestations of this disease vary widely, and the severity of symptoms varies, and there can be a rather long period of asymptomatic urinary abnormalities. In the early stage, there may be physical fatigue, lumbar and knee pain, poor performance, etc. Edema is sometimes absent. As the disease progresses, nocturia may gradually increase. Most patients have hypertension, and some patients have hypertension as the prominent manifestation. Renal function may be diminished to varying degrees. (b) Physical examination Chronic disease, some patients have edema. (ii) Examination (i) Urine routine It may show varying degrees of proteinuria and/or hematuria, and may have red blood cell tubular pattern. (ii) Blood routine Most patients have normal hemoglobin or mild anemia. White blood cells and platelets are mostly normal. (iii) Renal function Most patients can have a long period of stable renal function. As the disease progresses, late stage may show decreased urinary concentration function, elevated blood creatinine and decreased creatinine clearance. (iv) B-type ultrasound The kidney size is normal in the early stage, but bilateral symmetrical shrinkage and cortical thinning may appear in the late stage. III. Diagnostic criteria The diagnosis can be considered if the disease develops slowly and other secondary glomerular and/or tubulointerstitial diseases can be excluded, with clinical abnormalities in urine routine and different degrees of renal function decompensation. If there is no contraindication, renal biopsy is of great value in confirming the diagnosis, guiding treatment and assessing prognosis. Chinese medicine treatment: 1, spleen and kidney deficiency without edema type main symptoms: soreness and weakness of the waist and knees, dizziness, fatigue, laziness, lack of color, poor appetite and loose stools, pale tongue with white fur, weak pulse. Treatment: Strengthening the spleen and benefiting the kidney. Radix et Rhizoma Ginseng and Rhizoma Atractylodis Macrocephalae plus/minus. Radix Codonopsis Pilosulae 15g, Rhizoma Atractylodes 15g, Rhizoma Atractylodes 10g, Poria 20g, Coix Seed 15g, Radix Astragali 30g, Lotus 15g, Semen Gorgonii 20g, Primrose 20g, Radix et Rhizoma Glycyrrhiza Glabra 6g. Addition and subtraction: If the back is sore, add Eucommia 15g. If the abdomen is distended, add Chen Pi 10g, Abdominal Bark 30g. 2. Spleen and kidney Yang deficiency edema type Main symptoms: edema of the limbs and even the whole body, soreness of the back and cold limbs, pale face, loose stools The main symptoms are: edema of the limbs and even the whole body, lumbar soreness and coldness, pale complexion, loose stools, paucity of urine, clear urine, pale fat tongue, white greasy coating, sunken pulse. Treatment: Warming the kidney and promoting hydration. Formula: Zhen Wu Tang plus or minus. Radix et Rhizoma Pseudostellariae 6g, Poria 9g, Radix Paeoniae 9g, Radix Ginger 9g, Atractylodes Macrocephala 6g. Add and subtract: add Cinnamon 3g for kidney yang deficiency, 15g for oedema, 15g for Plantago ovata, 15g for Che Qian Zi to enhance the effect of diuresis, 30g for spleen deficiency, 15g for spleen and Qi. For evidence of blood stasis, add 10g of leech and 20g of motherwort to activate blood circulation and resolve blood stasis. For abdominal distension, add 12g of betel nut and 10g of mucuna pruriens. 3.Yin deficiency of liver and kidney, dampness and heat within the type Main symptoms: dizziness and tinnitus, lumbar soreness and weakness, dry mouth and throat, insomnia, yellow urine or astringent pain, or see blood in urine, or see mild swelling of limbs, red tongue with little coating, thin pulse. Treatment: Nourishing the liver and kidney, clearing heat and relieving dampness. Remedy: Zhi Bai Di Huang Tang with addition and subtraction. Zhi Mu 10g, Cornelian 10g, Sheng Di 15g, Ze Di 10g, Shan Yao 10g, Tu Fu Ling 40g, Dan Pi 12g, Xie Cao Root 30g, Zea Mays 30g. Add and subtract: dizziness and tinnitus add Qie Zi 15g, Chrysanthemum 12g, Hooked Vine (after the next) 15g, nourish Yin and submerge Yang; blood in urine add Xiao Ji 20g, Bai Mao Root 30g; urinary astringency and pain add Q Cao 10g, Qu Mai 10g Clear dampness and heat; add light bamboo leaf 10g, gardenia 10g to clear heat and remove irritation in cases of heartburn and insomnia. 4, Qi and Yin deficiency type Main symptoms: sore back and spermatorrhea, slight or no swelling of limbs, palpitation and shortness of breath, lack of color, fatigue or dry throat and mouth, no color, red tongue with little coating, thin pulse or hematuria. Treatment: Tonifying Qi and nourishing Yin. Formula: Ginseng and Astragalus Dihuang Tang with reduction. Radix Codonopsis pilosulae 12g, Radix Astragali 20g, Radix Astragali 10g, Cornu Cervi Pantotrichum 10g, Rhizoma Dioscoreae 10g, Poria 20g, Salvia 10g, Zeligia 10g. Addition and subtraction: for sore throat, add Medlar, Salvia, Radix Paeoniae to nourish Yin and invigorate blood; for heavy swelling of limbs, add Poria, Che Qian Zi to promote water retention and reduce swelling. 5. Deficiency of lumbar pain or stabbing pain, dark gray face, dry skin, or petechiae, petechiae, decreased urine output, swollen limbs, purple tongue or petechiae, astringent and sunken pulse or fine count. Treatment: Promote positive and expel evil, dispel blood stasis and promote circulation. Formula: Peach-Hong Siwu Tang with Addition and Reduction. Peach kernel 15g, safflower 10g, angelica 10g, Chuanxiong 10g, red peony 15g, motherwort 30g, salvia 20g, poria 15g, astragalus 20g, leech 10g. 6. Agreement formula: proteinuria as the main manifestation belongs to TCM Qi deficiency and blood stasis with proteinuria formula. 7. For proteinuria mainly manifested by Qi deficiency and blood stasis in TCM, use Renkang Pill 6g, taken orally 3 times a day. 8. Torchflower root tablets 5 tablets, orally, 3 times a day or Leigongtang polysaccharide tablets 20mg, orally, 3 times a day. Second, Western medical treatment 1, diet treatment High-quality low protein diet (0.6~0.8/kg per day), while controlling the intake of phosphorus in the diet. When eating a low-protein diet, the intake of carbohydrates should be increased appropriately to meet the calories required for the physiological metabolism of the body and to prevent negative nitrogen balance. 2.Essential amino acids Essential amino acids or a-keto acids (0.1~0.2g/kg.d.) can be used after 2 weeks of low protein diet. For very low protein diet, the intake of a-keto acids or essential amino acids (8~12g/d) should be increased appropriately. 3.Control of hypertension Mostly use angiotensin-converting enzyme inhibitors (such as mercaptopropionic acid 12.5~50mg/time, once every 8 hours) or calcium antagonists (such as Bysentone 30mg/time, once a day). As for other antihypertensive drugs such as ß-blockers, a-blockers, vasodilators and diuretics, they can also be used. In case of poor renal function, thiazide diuretics are ineffective or poorer and should be replaced with tab diuretics. 4, symptomatic treatment Prevention of infection, prevention of water-electrolyte and acid-base balance disorders, avoidance of nephrotoxic drugs is important to protect renal function and prevent progressive development of chronic renal disease and rapid deterioration of renal function. 5. ACEI or ARB antihypertensive drugs can be used to reduce proteinuria. [Efficacy criteria] I. Cured: clinical symptoms disappear, hematuria and proteinuria are negative, and renal function is normal; II. Third, not cured: clinical symptoms are obvious, hematuria and proteinuria persist, and normal or abnormal renal function.