Rapid prototyping (RP) is a kind of manufacturing technology that uses material stacking layer by layer or point by point method to manufacture physical objects. It is a comprehensive application of CAD/CAM, reverse engineering technology, layered manufacturing technology and other disciplines and technologies. The first rapid prototyping machine was produced in the United States in 1988, and subsequently, more than 10 different rapid prototyping technologies and corresponding equipment emerged, becoming one of the essential pillars of modern manufacturing. In the 21st century, with the maturity of rapid prototyping technology, the accuracy of model making has been greatly improved, and the application in various medical disciplines has gradually become one of the regular auxiliary techniques for clinical treatment, and the application in craniomaxillofacial surgery is also more than other specialties such as plastic surgery, and is increasing. Some foreign hospitals directly connect the rapid prototyping machine to CT as a diagnostic device, and provide the patient with a physical model of the corresponding part at the same time or later. At present, the molding accuracy of new rapid prototyping machines can all reach 0.1mm, and the 3D models made according to CT data can display the craniofacial 3D anatomical structures and their interrelationships in a three-dimensional and precise manner. The error between the model and the real individual is mainly determined by the accuracy of CT and the corresponding software for specific tissue selection. In the treatment of craniofacial bone defects or facial asymmetry, after establishing a 3D digital model of the jaw bone and establishing a digital model of the bone defect by the principle of mirror replication and data interpolation, the 3D solid craniofacial bone and the individualized prefabricated prosthesis model are manufactured by rapid prototyping machines, and the prosthesis and the patient’s original skeletal model are connected in vitro for trial assembly to correct defects in the design and fabrication of the prosthesis. Pre-operative pre-shaping of prosthetic materials, such as titanium plates and artificial bone, avoids the temporary matching shaping process during surgery; alternatively, individualized implant prostheses of various materials, such as hydroxyapatite, bone cement, etc., which are often not easily shaped intraoperatively, can also be made by mold or precision casting. Artificial titanium mandibular implants, including condyles, can be prepared directly from contralateral mandibular data. For the repositioning surgery of craniomaxillofacial fractures, due to the anatomical characteristics of craniofacial bones, unlike the long stem bones of limbs which have clear alignment marks, the model can be made after mirroring the bones on the healthy side, and the fixed titanium plate can be preformed, through which the displaced bone on the affected side can be guided to reset and restore the symmetrical shape. I. Application of computer-aided design and production in jaw fracture reconstruction CAD/CAM technology is a high-tech technology widely used in industrial automation and aerospace fields in the 1970s, which has greatly improved the production efficiency. In the late 1980s, CAD/CAM technology began to be used in oral and maxillofacial trauma and orthognathic surgery, especially in the reconstruction and repair of multiple comminuted mandibular, orbital wall, and zygomatic complex fractures, which are becoming more and more mature. Combined with RP and inverse engineering technology, CNC lathe processing of precision restorations, it can be said that the future restoration of dental and maxillofacial trauma will be more accurate and more widely carried out with the in-depth research on CAD/CAM, which will be another milestone in the field of dentistry to leap forward again in the 21st century. For the revision of old maxillofacial fractures, the classic traditional method is to cut the soft tissue, osteotomy to re-fracture, reset and internal fixation. However, the final result of this method is often unsatisfactory, and the patient’s appearance and occlusal function, especially the former, cannot be perfectly restored, which is mainly related to the fact that the fracture line is not obvious after the healing of the fracture dislocation and some normal anatomical reference points of the maxillofacial surface are not obvious, the following is an example of the application of CAD/CAM in the diagnosis and treatment of maxillofacial fractures, using computer-aided zygomatic-orbital bone reconstruction as an example: the CT data of the patient’s zygomatic-orbital bone is input into The CT data of the patient’s zygomatic orbital bone is input into the image processing software to generate a standard template library (STL) format 3D image file of the zygomatic orbital bone, and then the file is input into the software, and the affected zygomatic orbital bone is duplicated by flipping the healthy side with the midline as the axis using the mirroring tool to obtain symmetrical bilateral normal images of the zygomatic orbital bone. A 3D model of the affected zygomatic orbital area was created by the rapid prototyping technique, and a titanium mesh or titanium plate was formed on it. The study concluded that the computer-aided technique of making personalized titanium mesh is better than the traditional reconstruction method in reconstructing the zygomatic orbital morphology, and it can reconstruct the zygomatic orbital area more precisely, especially for the old fracture of the zygomatic orbital area. II. Progress in treatment of dental trauma The results of dental trauma include loss of dental tissue and tooth loss. The current methods of replacing missing teeth mainly include movable and fixed prostheses and dental implant restorations. This replacement of natural, physiologically functional dental tissues with artificial materials has continued from ancient times, but it has failed to completely replace all the physiological functions of human teeth. Research has been conducted to explore the use of human stem cell regeneration for dental trauma treatment, and certain research results have been achieved. Stem cells are primitive, undifferentiated cells with multiple differentiation potentials and the potential to differentiate into other cell types. This “ability” allows stem cells to act as the body’s repair system for specific tissues or organs, which is why stem cell medicine is also known as regenerative medicine. Before stem cells can be transplanted into human tissue to begin regeneration, they must be pre-programmed to become specific cells. These cells are then injected into the part of the body where tissue regeneration is needed. After the stem cells come in contact with the growth chemicals in the body, they are promoted by the chemicals to develop into the tissue around it. Dental stem cells are multifunctional adult stem cells, which can be isolated from different parts of the tooth such as pulp, periodontium, capsule and apical papillae. Many studies have confirmed that dental stem cells can differentiate into enamel cells, osteoblasts, chondrocytes and pulp cells, which have good functions in repairing dental tissues. Both milk teeth and permanent teeth contain stem cells, and the stem cells in milk teeth are more active and have a higher number of stem cells than those in general adult teeth, which is more useful for dental regenerative medicine research. The main goals of dental stem cell research: repair of partially missing dental tissue and regeneration of new, complete bioengineered teeth. Different techniques have been reported for the fabrication of bioengineered teeth. Methods using tooth-shaped scaffolds combined with stem cell colonization, or a mixture of different types of cells, including non-dental stem cells that have the ability to form bioengineered teeth. The process of regenerating a bioengineered tooth is very complex because of the different options available for scaffold materials, cell numbers and cell aggregation methods.