When HPV infects men, some patients are asymptomatic and some develop localized growths such as condyloma acuminata. Giant condyloma is a precursor to penile cancer, mainly manifested as new organisms, which may appear on the surface of the patient’s skin as clusters or cauliflower-like hard tissue, which may be brown, brown or black in color, with a diameter of 0.3-0.5mm when small in size, but may be more than 1cm in diameter when large in size and difficult to recover by pressure. The treatment of HPV infection should be based on focal treatment, including laser, freezing, excision and other methods, to remove the abnormal masses of the infection.