Premature ejaculation is the most common type of male ejaculatory dysfunction. It is widely seen in patients of all ages after marriage, and its incidence is as high as about 50%, making patients and their families very distressed, making male doctors very confused, giving us the feeling that we are helpless. However, as a male doctor, Dr. Zuo, I do not see it this way. I have defended “premature ejaculation”, but today I can’t defend it anymore, so let’s discuss what is going on with premature ejaculation. When a man has sex with his spouse, there is a physiological latency period for ejaculation, that is, the length of time we control ejaculation (the strength of our control ability). Normal men are in the range of 3 to 35 minutes (average 10 minutes ± 9.5 minutes), while the vast majority of patients with premature ejaculation lose the ability to control the ejaculatory reflex at will, and their ejaculatory latency is only in the range of 0 to 3 minutes (average 1.57 minutes ± 1.15 minutes), which shows that the short ejaculatory latency of men causes anxiety about the sexual satisfaction of both spouses is the main conflict of patients with premature ejaculation. These patients have a variety of conditions, but anxiety caused by a variety of symptoms is common to them. So, why do patients with premature ejaculation have problems with their ejaculatory latency? Many medical experts have worked extremely hard on this. They started with studies on the epidemiology of premature ejaculation; from the physiology of ejaculation in men; from the pathophysiology of premature ejaculation, until recent studies showed that among patients diagnosed with premature ejaculation, those with prostatitis or infection were significantly higher than the control group. I personally strongly agree with this insight, including aseptic prostatitis, and so many, many people with this problem have ejaculated prematurely during their masturbatory behavior when they were not married. I think long-term chronic congestion of the genitourinary system (due to masturbation) is also one of the main causes of premature ejaculation after marriage or when in contact with women. Of course, prostatitis or infection is an important cause of short ejaculation latency in premature ejaculation patients. Other diseases are hyperthyroidism and premature ejaculation. A multi-center study showed that the prevalence of premature ejaculation in hyperthyroid men was as high as 50%, which we did not recognize before. Experts say that after normalizing thyroid hormones with medication, the incidence of premature ejaculation decreased from 50% to 15%, and ejaculatory latency doubled after treatment (from 2.4 minutes ± 2.1 minutes to 4.0 minutes ± 2.0 minutes, P0.01).