Chest tightness and heartburn can be seen in coronary angina, reflux esophagitis and other diseases, can be given for the cause of the general treatment, drug therapy. 1. Coronary angina: patients with coronary artery disease have serious coronary artery stenosis, myocardial ischemic attack can be manifested as chest pain, some patients with symptoms are not particularly typical, can be manifested as chest tightness symptoms, accompanied by burning sensation, coronary artery angiography can be carried out for a clear diagnosis of the treatment should be given to aspirin, atorvastatin, isosorbide nitrate and other medications, intervention and other treatments, when necessary. 2. Reflux esophagitis: the refluxed food will cause irritation to the esophagus, patients can be accompanied by a burning sensation behind the sternum, some patients can have the symptom of chest tightness, easy to misdiagnose as coronary artery disease. It can be examined by gastroscopy, and the treatment is to give drugs such as mosapride and omeprazole. Patients with chest tightness and heart burning, if the symptoms are more obvious, should go to the hospital in time, under the guidance of physicians for diagnosis and treatment.