Hp infection can lead to prolonged peptic ulcers, and eradication of Hp in Hp-infected ulcer patients will facilitate ulcer healing and prevent recurrence after healing. Since the recommendation of Hp treatment protocol, there has been a consensus on the treatment of Hp, and the eradication rate of Hp has reached a more satisfactory level. However, the eradication rate of Hp has decreased in recent years, and even repeated treatment has not significantly improved, which is mainly due to the emergence of drug-resistant strains of bacteria. In a study by Liang Xiao et al, the resistance rate of metronidazole was 49.7%, clarithromycin 7.3%, amoxicillin and furazolidone 1.2%. Resistance to clarithromycin is mostly primary resistance and prolonging the treatment does not improve the eradication rate. Some studies have concluded that almost 100% of all treatment failures are resistant to metronidazole, and some patients still fail after entering second-line therapy, which is related to the fact that the current antibiotics are mainly imidazole (metronidazole, tinidazole), clarithromycin and tetracycline. Therefore, for those who fail in first-line treatment, remedial treatment or alternative regimens can be switched to avoid imidazoles or macrolides as much as possible, and drugs with lower resistance rates can be used instead, such as furazolidone, levofloxacin, and ecabet. Levofloxacin has strong antibacterial activity against various gram-positive bacteria, and can be used as an alternative to clarithromycin. As the rate of clarithromycin resistance is gradually increasing, levofloxacin new triple therapy has a better comprehensive evaluation and can be used as a first-line treatment or remedial treatment option for second-line treatment in drug-resistant areas. stable in acidic environment, less resistant strains, less adverse effects, and inexpensive, has been an important drug in combination therapy regimen; 3. PPI inhibits gastric acid secretion and enhances the effect of other antibiotics by raising the pH in the stomach more than H2 receptor blockers. Therefore, the new triple therapy containing levofloxacin can be the first choice of therapy for Hp infection.