Chronic urticaria is a condition in which the local blood vessels or skin are affected by various factors and become edematous or congested, resulting in a series of edematous patches on the epidermis that last for a long time. Chronic urticaria can be triggered by many factors, such as improper diet, drug allergies and infections and insect bites, as well as gastrointestinal diseases and endocrine factors, all of which may lead to this problem. The treatment is also more troublesome, easy to repeatedly multiple attacks, the eradication is more difficult, mainly drug treatment. At present, a variety of treatments are available, including antihistamines and glucocorticoids, as well as some immunosuppressive drugs. There are differences in the use of medications for hives caused by different triggers, such as anti-infective drugs for infectious hives, and antihistamines such as paracetamol for hives caused by sun exposure. Patients with allergic causes themselves can also be managed using anti-allergy therapy. The specific drugs to be taken orally are required by the doctor to determine the type of disease of the patient and then based on the individual situation before an effective treatment plan can be developed. In addition, the most effective way to prevent chronic urticaria is to identify the cause of the disease through a series of tests such as serology and allergen testing, and to avoid contact with the causative agent in general, which can greatly reduce the chances of recurrence. Chronic urticaria is caused by many factors, and medication can be used to achieve better results.