Novel coronavirus may be present on the soles of shoes. Novel coronavirus pneumonia is spread mainly by respiratory droplets, and patients or asymptomatic infected persons can carry the virus and bring it into the environment by talking, breathing, sneezing, or by contaminated hands, and the virus may be present on surfaces and floors. The virus is not very resistant in the outside environment and usually survives for a few hours, but if the virus is present on the floor indoors during this time, it can be picked up by the soles of shoes and carried to other environments with walking. So contact with patients with novel coronavirus pneumonia must be secondary or tertiary protection, and shoe covers should be worn. If during a novel coronavirus pneumonia epidemic, pay attention to the disinfection of the environment and the disinfection of object surfaces. Enter the environment to disinfect the soles of shoes and clothing surfaces, which can be sprayed with 75% alcohol or chlorine-containing preparations. Pay attention to more ventilation indoors, especially in confined spaces, such as elevator rooms, to disinfect them.