Dry cracked skin pain on both sides of the buttocks may be caused by local soft tissue injury, may also be due to perianal eczema, neurodermatitis, ringworm or excessive skin dryness, etc., it is generally recommended that targeted treatment according to the different causes.1, soft tissue injury: if the local skin is subjected to trauma, it may cause soft tissue injury, resulting in local skin dry cracks and pain symptoms. At this time you need to use iodine or saline for rinsing and anti-inflammatory, and oral antibiotic drugs, such as cefixime, cefuroxime, etc.; 2, perianal eczema: this disease may be wearing non-cotton underwear, localized excessive friction related to, but also can not be ruled out is the cause of hereditary allergic body, which may lead to the anal periphery or buttocks skin with varying degrees of erythema, blisters, accompanied by localized peeling, dry cracks, Pain and other symptoms, at this time you can use tacrolimus ointment, pimecrolimus cream for external application. If the local symptoms are more serious, there are also bacterial infections, but also need oral amoxicillin, ceftazidime and other drugs to assist in the treatment; 3, neurodermatitis: this disease is mainly closely related to neurological factors, but also due to the consumption of spicy, stimulating diets or drinking alcohol and other reasons, generally cause the buttock skin flat pimples and accompanied by itchy, cracked and painful symptoms. Generally, you can use local menthol ointment, glycerine lotion treatment, to play the effect of itching. If the local itching is more serious, you also need to take oral loratadine tablets to assist in the treatment; 4, ringworm: mainly associated with fungal infections, such as dermatophytes, but also may be caused by living in a hot or humid environment for a long time, which may induce ringworm, causing local skin erythema, flaking, slight dry cracking and pain symptoms. At this time, you can apply local clotrimazole cream, if the symptoms worsen, you can also take oral itraconazole, terbinafine for antifungal treatment; 5, excessive skin dryness: if you do not pay attention to skin hydration and moisturizing, or a large number of vitamins are lacking, may lead to particularly dry skin, skin, itching, tingling, and mild dry cracking symptoms. Can be regulated by oral vitamin A, vitamin B, and need to apply moisturizing skin cream. It is also important to drink plenty of water and eat plenty of fresh vegetables and fruits.