Patients with ventricular premature beats should not smoke. Smoking is very harmful to patients with ventricular premature beats, mainly because the presence of nicotine and tar in cigarettes can increase the oxygen consumption of the heart, which can lead to further myocardial ischemia and hypoxia, thus aggravating the onset of ventricular premature beats. In addition, smoking can produce carbon monoxide, which can damage the cardiovascular endothelium and increase myocardial hypertrophy, causing diastolic and systolic dysfunction of the heart, thus leading to more severe ventricular premature contractions. For patients with ventricular premature beats, long-term heavy smoking can also lead to ventricular tachycardia, eclipse fibrillation, and even sudden cardiac death.