Severe peeling of the soles of the feet in diabetic patients may be diabetic foot, foot infection and other conditions, which usually require treatment such as lowering blood glucose, anti-infection, protecting blood vessels and other treatments, mainly medication, including oral medication and topical medication. Patients should first control their blood sugar, improve their lifestyle, avoid eating high sugar and high fat foods, and control the total calories they eat daily. Exercise more often, physical exercise, obese people appropriate weight loss. Follow the doctor’s instructions to take medication regularly to control blood sugar, such as metformin, acarbose, etc., and subcutaneous injection of insulin therapy if necessary. Foot infections can also cause peeling of the soles of the feet, which may be caused by pathogenic microorganisms such as fungi and bacteria, and can be treated with appropriate medications, including oral medications and topical medications. Keep the feet clean and dry. In addition, if the patient lacks vitamin B, it may also lead to severe peeling of the soles of the feet, and can be supplemented with vitamin B appropriately. Patients should not take medication on their own, and it is recommended that patients seek medical treatment in time and under the guidance of the doctor.