1, choose new aminosalicylates Aminosalicylates are still the main drugs for the treatment of mild to moderate ulcerative colitis treatment, can induce remission and maintain remission, new aminosalicylates can make more than 50% of patients with mild to moderate ulcerative colitis achieve mucosal healing. After remission is achieved, continued long-term medication is required to maintain mucosal healing and reduce the incidence of recurrence and complications. Jiang Xueliang, Department of Gastroenterology, General Hospital of Jinan Military District, Jinan, China 2. Adopt appropriate biological therapy Clinical observation of the application of biological therapy to patients with recalcitrant or hormone-dependent resistant ulcerative colitis. Preliminary results show that biological treatment of hormone-resistant ulcerative colitis patients has a rapid onset of action and high clinical efficiency. Another advantage of biologic therapy for hormone-resistant ulcerative colitis is that it promotes intestinal mucosal healing, and symptom relief is generally consistent with histological relief. Therefore, for patients with intractable ulcerative colitis, early and active application of biologic therapy is expected to induce remission more quickly, and long-term application can maintain longer remission and maintain endoscopic mucosal healing and withdrawal of hormones, thus reducing hospitalization and surgery rates and providing new therapeutic tools for the treatment of patients with intractable ulcerative colitis. 3. Combined application of cellular therapy Preliminary clinical observation of patients with recalcitrant or hormone-dependent resistant ulcerative colitis shows that it can not only make patients’ diarrhea mucus and blood stool symptoms disappear, but also make the diseased colonic mucosa achieve mucosal healing. In conclusion, although the repair of the damaged intestinal mucosal barrier in patients with persistent ulcerative colitis is still a very difficult and urgent clinical problem, most patients are able to achieve and maintain mucosal healing in the long term with comprehensive and individualized treatment according to their conditions. Each patient needs to be seen in person to determine the appropriate treatment plan.