What are the causes of celiac disease?

Celiac disease is not really celiac disease Celiac disease is a frequent and common disease among women. The incidence rate is as high as 40% to 60% among married women. The female cervix is divided into an inner and outer opening. The endocervical epithelium is a thin, mucus-secreting red columnar cell, and the exocervix is covered by a grayish-yellow squamous epithelium. Under certain factors, the squamous epithelium of the outer opening of the uterine cervix becomes covered by the columnar epithelium and celiac disease is formed. Colposcopic observation of the surface of the erosion, in fact, complete columnar epithelium, because the columnar epithelium is a single layer, the mesenchymal stroma underneath is red, so the naked eye observation of the red erosion-like. This shows that cervical erosion is not really erosion, compared with the normal smooth cervix, just intuitively feel like erosion. Colposcopic observation of the cervix “celiac disease” is the squamous column junction transformation area. Many women are accidentally found to have celiac disease during a normal medical checkup without any previous symptoms. Why is this? This is because celiac disease itself is not inflammatory, that is, it is not a pathological sense of epithelial loss and inflammatory reaction, but the cervical columnar epithelium is ectopic, is one of the physiological changes of the cervix, not a pathological change. When there is no pathogenic microbial infection, i.e., when there is no inflammation, patients with celiac disease may have no clinical symptoms, or only show increased secretions. Some patients may have bloody leukorrhea or bleeding after intercourse. Of course, there are some patients with more severe symptoms, in addition to abnormal leukorrhea, there may also be back pain, vulvar and vaginal itching and other symptoms. However, this is not due to celiac disease itself, but mostly due to the combined inflammatory infections. Sex is not the direct cause of celiac disease Some people believe that celiac disease is caused by sex, so once diagnosed with celiac disease, they are quite rejected to have sex. In fact, this view is wrong. At present, the real etiology of cervical celiac disease is still not clear, it is generally believed that mechanical stimulation or injury after marriage, such as childbirth, abortion or too frequent sex life, can cause different degrees of cervical squamous epithelial destruction, cervical local resistance is reduced, easy to cause cervical inflammation. However, clinical findings, no sex life of women, there is still cervical erosion, sometimes even severe erosion. This shows that sexual life is not the culprit that leads to celiac disease. At the same time, experts remind unmarried, or sexually inactive women, if there is a persistent increase in leukorrhea, or accompanied by changes in color and texture, should also be timely to the gynecological clinic, in order to identify the cause, timely treatment. Celiac disease does not necessarily lead to infertility In the past, it was believed that celiac disease is often accompanied by inflammation, and the inflammatory cells will phagocytosis of sperm, but also lead to a change in the nature of cervical mucus, which prevents sperm from penetrating the cervical mucus to reach the uterine cavity. As the sperm cannot reach the uterine cavity successfully, it naturally fails to meet the egg, and conception is not possible. However, it is now found that in more young women, celiac disease is only a change in the type of cervical epithelial cells and is not associated with an inflammatory infection, and therefore does not lead to infertility. For women who are ready to get pregnant, if celiac disease is not accompanied by any symptoms, fertility experts recommend that they should actively try to get pregnant without rushing to do much treatment for celiac disease. If there is excessive leukorrhea or yellowing of the leukorrhea that is causing discomfort, it can be treated with appropriate medication and pregnancy can be attempted after the symptoms improve. Celiac disease has nothing to do with cancer Many women with celiac disease are worried about cervical cancer, believing that the heavier and longer the celiac disease is, the more likely it is to develop cervical cancer. Theoretically, cervical erosion is a pathological change, i.e., it is caused by the replacement of the squamous epithelium of the cervix by the columnar epithelium, rather than true erosion. Cervical cancer, on the other hand, is an abnormal change in the squamous epithelium of the cervix, mainly due to human papillomavirus (HPV) infection. The two have different causes and pathogenesis, and different pathologic changes. Therefore, simple cervical erosion, if not combined with HPV infection, does not lead to cervical cancer. However, women with celiac disease should be reminded that during gynecological examination, cervical exfoliative cytology should be performed to preliminarily exclude the possibility of cervical cancer. Because it is difficult to distinguish early cervical cancer from celiac disease during gynecological examination alone. If possible, HPV test should be performed at the same time of cervical exfoliative cytology examination to exclude the possibility of cervical cancer and precancerous lesions. In recent years, there have been some new concepts in the academic world regarding the management of cervical celiac disease. When there is no pathogenic microbial infection, cervical erosion may have no clinical symptoms or only show increased secretion, and no treatment is needed. (1)<30 years old, for simple, superficial erosion is mostly physiological changes, without special treatment. (2)>30 years old, or granular erosion, asymmetric erosion, with contact bleeding, cervical hardness is different, should be cervical lesion three-step screening, except cervical lesions. (3) Granular or papillary erosion should be treated if combined with inflammatory symptoms such as increased leukorrhea and vulvovaginal itching. In cases where cervical cancer is excluded, physiotherapy is mostly advocated. (4) Physiotherapy has more methods, but the treatment principle is the same and the efficacy is similar. The key is to grasp the correct indications, standardize the operation and pay attention to the treatment period. Does physiotherapy have any effect on pregnancy and labor in the future? Physical methods such as laser treatment may cause slight damage to the cervix, which may affect the dilatation of the cervix during labor and delivery in the future. It is best to go to the hospital for a checkup before you plan to get pregnant. If the celiac disease does not affect your pregnancy or is not associated with an acute infection, you can get pregnant first, and then undergo laser treatment after delivery. However, if your condition requires it, you should still follow your doctor’s advice and actively cooperate with the treatment. In principle, physical therapy only destroys a layer of cells on the surface of the cervix, and through damage repair, the columnar epithelial cells are transformed into squamous epithelial cells, thus treating cervical erosion, so physical therapy will not lead to narrowing of the cervical opening, not to mention infertility.